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Contribution of Ivermectin in Pharma industry There are 1 replies:
Contribution of Ivermectin in Pharma industry Original post: Mon 10/18/2021 at 8:03 AM

Ivermectin is a powerful macrocyclic lactone that causes paralysis in many nematodes and arthropods due to the influx of chloride ions through the cell membrane. Currently, it is the best drug for human onchocerciasis and has strong microfilariasis activity against other major human filariasis parasites (Wuchereria bancrofti, Brugia malayi, Loa loa, Mansonella perstans). As shown, this is not the case for resident filariasis. Whether it also kills the adult stage of these parasites is currently under investigation. Ivermectin is also very effective in both human strongyloidiasis and the migration of skin larvae for which good alternative treatments have not been available. And it is as effective as the drugs currently available against the enterobacteriaceae Ascaris lumbricoides , Trichuristrichiura and Enterobius vermicularis . It has only partial effect on human hook worms. Preliminary studies have shown that ivermectin may also be the optimal drug for the spread of human ectoparasites (mites, lice).

Ivermectin is a powerful macrocyclic lactone that causes paralysis in many nematodes and arthropods due to the influx of chloride ions through the cell membrane. Currently, it is the best drug for human onchocerciasis and has strong microfilariasis activity against other major human filariasis parasites (Wuchereria bancrofti, Brugia malayi, Loa loa, Mansonella perstans). As shown, this is not the case for resident filariasis. Whether it also kills the adult stage of these parasites is currently under investigation. Ivermectin is also very effective in both human strongyloidiasis and the migration of skin larvae for which good alternative treatments have not been available. And it is as effective as the drugs currently available against the enterobacteriaceae Ascaris lumbricoides , Trichuristrichiura and Enterobius vermicularis . It has only partial effect on human hook worms. Preliminary studies have shown that ivermectin may also be the optimal drug for the spread of human ectoparasites (mites, lice).Much has been learned about the biochemical mechanism by which ivermectin acts on nematodes and arthropods, but as always, new discoveries raise even more interesting questions. However, paralysis of parasites affected by ivermectin is due to the influx of ions through the cell membrane, which appears to block the action potential of the cell.

The mechanisms of these processes are being investigated intensively. Indeed, ivermectin generics in other human infectionsThe usefulness of is not as clear as in the case of onchocerciasis. This is due to the variable efficacy in these other infections and the availability of other effective drugs for many of these infections. In the case of human filariasis (excluding onchocerciasis), the potential value of ivermectin ultimately depends on the degree of macrofilariasis activity demonstrated in current and future studies. Once effective in adulthood, ivermectin may be the drug of choice for Wuchereria bancrofti, Brugia malayi, Wuchereria bancrofti, and Wuchereria bancrofti infections. It does not seem to be active against resident filamentous insects. In the treatment of intestinal nematode infections, ivermectin, A . Lumbricoides , E . Accepted as an alternative to vermicularis , and T. trichiura 's current drug, but not a good alternative. Not as effective as other drugs for human hookworm infections ( caused by N.americanus and A. duodenale ), but of choice for skin larval migration (caused by non-human hookworm larvae) May become. Ivermectin is very effective against S. stercoralis and may be the best drug for the treatment of strongyloidiasis

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Re: Contribution of Ivermectin in Pharma industry Posted: Tue 10/19/2021 at 6:19 AM, in reply to guest guest

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